细胞毒性药物用于癌症化疗的数十年经验,表明这些药物可起免疫调节作用,而且药物治疗对免疫反应的作用,是受给药时病人的免疫活性所影响,本文研究化疗时自然杀伤(NK)细胞功能的作用。作者观察非小细胞性肺癌(18例)、结肠癌及黑色素瘤(各1例)病人治疗前与第一轮化疗期中(每周1次)外周血NK细胞功能。化疗包括由环磷酰胺、阿霉素,氯甲喋呤、5-FU、顺氯氨铂、盐酸甲基苄肼等药物组成之联合化疗方案,或单独5-FU(结肠癌)、甲基CCNU(黑色素瘤)化疗。外周血单个核细胞(PBMC)中NK细胞功能以K562细胞株作靶细胞,用~(51)Cr释放法测定。结果以细胞毒的百分数表 The decades of experience in cytotoxic drugs for cancer chemotherapy have shown that these drugs can play an immunoregulatory role, and that the effect of drug treatment on immune responses is affected by the patient’s immune activity during administration. This study investigated the natural killing effect of chemotherapy ( The role of NK) cell function. The authors observed peripheral blood NK cell function in patients with non-small cell lung cancer (18 cases), colon cancer, and melanoma (1 case each) before treatment and during the first round of chemotherapy (once per week). Chemotherapy consists of a combination chemotherapy regimen consisting of cyclophosphamide, doxorubicin, chloromethyl purine, 5-FU, cisplatin, procarbazine hydrochloride, or 5-FU (colon cancer) and methyl alone. CCNU (melanoma) chemotherapy. The function of NK cells in peripheral blood mononuclear cells (PBMCs) was K562 cell line as a target cell and was measured by ~(51)Cr release method. Results with the percentage of cytotoxicity