论文部分内容阅读
目的：探讨甲地孕酮（ＭＡ）对肿瘤化疗病人生活质量的影响。方法：６４例恶性肿瘤患者按病例配对法分成ＭＡ组（化疗＋ＭＡ）和对照组（单用化疗），二者化疗方案相同，均用二周期；ＭＡ为１６０ｍｇ／ｄ，连用６０ｄ。观察两组治疗前后食欲、食量、体质量和Ｋａｒｎｏｆｓｋｙ评分的改变，以及化疗效果、胃肠反应、骨髓抑制情况。结果：ＭＡ组食欲、食量、体质量和Ｋａｒｎｏｆｓｋｙ评分的增加明显好于对照组，而化疗效果、胃肠反应、骨髓抑制则无显著性差异；未发现明显的副反应。结论：小剂量ＭＡ可改善肿瘤化疗患者的生活质量。
Objective: To investigate the effect of megestrol (MA) on the quality of life of patients undergoing chemotherapy for cancer. Methods: 64 patients with malignant tumors were divided into MA group (chemotherapy + MA) and control group (chemotherapy alone) according to the case-matching method. The two chemotherapy regimens were the same and used two cycles; MA was 160 mg/d and used for 60 days. The changes of appetite, food intake, body weight and Karnofsky score before and after treatment were observed, as well as the effects of chemotherapy, gastrointestinal reactions, and myelosuppression. Results: The increase of appetite, food intake, body weight and Karnofsky score in MA group was significantly better than that in control group. There was no significant difference in chemotherapy effect, gastrointestinal reaction and bone marrow suppression. No obvious side effects were found. Conclusion: Small doses of MA can improve the quality of life of cancer chemotherapy patients.