缩醛是许多药物和天然产物分子中常见的结构单元,研究发现手性缩醛的生物活性通常优于其消旋体.由于手性缩醛存在消旋化倾向,其催化不对称合成具有挑战性,近年来才引起关注.综述了目前手性N,N-缩醛、N,O-缩醛、N,S-缩醛、O,O-缩醛的催化不对称合成研究进展,及其在含缩醛骨架手性药物合成中的应用. Acetals are common structural units found in many drug and natural product molecules and chiral acetals have generally been found to have superior biological activity over racemates. As chiral acetals tend to racemise, their catalytic asymmetric synthesis poses challenges In recent years, attention has been paid to the progress of the catalytic asymmetric synthesis of chiral N, N-acetals, N, O-acetals, N, S-acetals and O, O-acetals Application of chiral drugs with acetal skeletons.