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目的:探讨Vitapex糊剂填充治疗根尖周炎患者的效果及对患者血清C反应蛋白(CRP)、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平的影响。方法:选择舟山市妇幼保健院2017年5月至2019年5月收治的根尖周炎患者122例，采用随机数字表法分为观察组61例与对照组61例。观察组采用Vitapex糊剂填充，对照组采用传统根管糊剂填充。两组均随访3个月评价。比较两组治疗效果，治疗前后根管菌落数、视觉模拟评分法(VAS)评分及血清CRP、IL-6和TNF-α水平变化。结果:观察组总有效率(95.08%)高于对照组(80.33%)(χn 2＝6.157，n P<0.05)；观察组治疗后根管菌落数[(2.51±0.48)CFU]，低于对照组的[(9.93±1.25)CFU](n t＝43.280，n P<0.05)；观察组治疗后VAS评分[(1.12±0.28)分]，低于对照组[(2.09±0.37)分](n t＝16.327，n P<0.05)；观察组治疗后血清CRP[(6.59±1.23)mg/L]、IL-6[(1.21±0.26)μg/L]和TNF-α[(3.12±0.43)μg/L]，均低于对照组[(11.37±2.74)mg/L、(1.73±0.35)μg/L和(5.42±0.80)μg/L](n t＝12.430、9.315、19.778，均n P<0.05)。n 结论:采用Vitapex糊剂填充治疗根尖周炎患者效果良好，可减轻疼痛，减轻炎性反应。“,”Objective:To investigate the effect of Vitapex paste on periapical periodontitis and the changes of serum C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α).Methods:From May 2017 to May 2019, 122 patients with periapical periodontitis admitted to Zhoushan Maternal and Child Health Hospital were randomly divided into observation group (61 cases) and control group (61 cases) according to the random digital table method.The observation group was filled with Vitapex paste, while the control group was filled with traditional root canal paste.Both two groups were followed up for 3 months.The results of the two groups were compared before and after treatment, including the number of mycorrhizal colonies, visual analogue score (VAS), serum CRP, IL-6 and TNF-α levels.Results:The total effective rate of the observation group (95.08%) was higher than that of the control group (80.33%) (χn 2=6.157, n P<0.05). The number of colonies in root canal [(2.51±0.48)CFU] of the observation group was lower than that of the control group [(9.93±1.25)CFU] (n t=43.280, n P<0.05). After treatment, the VAS score of the observation group[(1.12±0.28)points] was lower than that of the control group[(2.09±0.37)points](n t=16.327, n P<0.05). The serum levels of CRP [(6.59±1.23)mg/L], IL-6 [(1.21±0.26)μg/L] and TNF-α [(3.12±0.43)μg/L] in the observation group were lower than those in the control group [(11.37±2.74)mg/L, (1.73±0.35)μg/L and (5.42±0.80)μg/L] (n t=12.430, 9.315, 19.778, all n P<0.05).n Conclusion:Vitapex paste can reduce pain and inflammatory response in the treatment of patients with periapical periodontitis.