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目的:优化灯盏花素微乳处方,并对其理化性质进行考察。方法:绘制伪三元相图,确定各相的比例,以载药量、粒径及粒径分布为评价指标,采用单纯形网格法优化微乳处方,并考察优化微乳的黏度、pH、电导率、粒径分布等理化性质。结果:选用Labrafil M1944cs(10%),Kolliphor RH40(30%),PEG400(60%)制备微乳,所得微乳平均粒径约为27 nm,粒径分布(PDI)平均值为0.198。响应方程预测的指标值与实测值相近。所得优化微乳性质稳定。结论:单纯形网格法能够客观的优化微乳处方,优化所得微乳载药量高,粒径小,分布均匀。所建立的响应方程能够准确的对微乳的载药量、粒径及粒径分布进行预测。
Objective: To optimize the prescription of Breviscapin microemulsion and investigate the physicochemical properties. Methods: The pseudo-ternary phase diagram was drawn and the proportion of each phase was determined. The drug loading, particle size and particle size distribution were used as the evaluation indexes. The simplex grid method was used to optimize the microemulsion prescription. The optimum microemulsion viscosity, pH , Conductivity, particle size distribution and other physical and chemical properties. Results: Microemulsion was prepared with Labrafil M1944cs (10%), Kolliphor RH40 (30%) and PEG400 (60%). The average particle size of the obtained microemulsion was 27 nm and the average PDI was 0.198. The index values predicted by the response equation are similar to the measured values. The resulting optimized microemulsion is stable in nature. Conclusion: The simplex grid method can objectively optimize the prescription of microemulsions, and optimize the obtained microemulsions with high drug loading, small particle size and uniform distribution. The established response equation can accurately predict the drug loading, particle size and particle size distribution of the microemulsion.