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目的制备伏立康唑PLGA纳米微粒,并分析其形态及释放特点。方法采用乳化-溶剂挥发法制备伏立康唑PLGA纳米微粒,用激光粒径分析仪及扫描电镜分别进行分散性和形态学分析,经HPLC分析其载药量及释放特点。结果经激光粒径分析,样品粒径峰值为(126±20)nm,分布指数为1.5。电镜观察颗粒分布均匀,表面光滑。HPLC分析载药量为(1.9±0.6)%,包封率约为12%,24h内存在突释,第2天到第8天缓慢释放。结论已成功制备了伏立康唑PLGA纳米微粒,能实现缓慢释放,减少给药次数的目的。
Objective To prepare voriconazole PLGA nanoparticles and analyze their morphology and release characteristics. Methods Voriconazole nanoparticle nanoparticles were prepared by emulsion-solvent evaporation method. The particle size and morphology were analyzed by laser particle size analyzer and scanning electron microscope, respectively. The drug loading and release characteristics were analyzed by HPLC. Results After laser particle size analysis, the peak value of particle size was (126 ± 20) nm and the distribution index was 1.5. Electron microscopy particle distribution, smooth surface. The drug loading was (1.9 ± 0.6)% by HPLC. The entrapment efficiency was about 12%. Burst was observed within 24 hours and slowly released from the second day to the eighth day. Conclusion Voriconazole nanoparticle nanoparticles have been successfully prepared for slow release and reduction of administration times.