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目的:探讨儿童矮小的病因,为临床诊治提供参考依据。方法:回顾性分析矮身材儿童487例的临床资料,采用统一诊断标准,通过详尽病史采集、体格检查、实验室检查明确病因。应用SPSS 13.0软件分析不同矮小儿童性别及年龄因素是否存在差异。结果:矮身材患者487例中GHD 297例占60.99%,ISS 89例占18.28%,SGA 38例占7.80%。不同病因矮身材儿童组内男女比较差异无统计学意义(P>0.05),7～12岁及≥13岁两组与≤6岁年龄段患儿构成比比较差异有统计学意义(P<0.01)。结论:在矮身材儿童病因中以生长激素缺乏症最为多见,其次为特发性矮小。对于矮身材患者或生长缓慢的儿童,家长应及早发现并及时就诊进行干预。
Objective: To explore the causes of dwarfism in children and provide reference for clinical diagnosis and treatment. Methods: The clinical data of 487 short stature children were retrospectively analyzed. The diagnostic criteria were adopted. The detailed medical history, physical examination and laboratory examination were used to confirm the cause. SPSS 13.0 software was used to analyze the differences of gender and age in different short children. Results: Among 487 short stature patients, 297 cases of GHD accounted for 60.99%, 89 cases of ISS accounted for 18.28% and 38 cases of SGA accounted for 7.80%. There was no significant difference between boys and girls in different stature of short stature children (P> 0.05), there was significant difference in the composing ratio of children between 7-12 and ≥13 years old and ≤6 years old (P <0.01) ). CONCLUSIONS: Growth hormone deficiency is the most common cause of short stature in children, followed by idiopathic short stature. For short stature patients or children with slow growth, parents should be detected as soon as possible and timely medical intervention.