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目的探讨硬化性上皮样纤维肉瘤的病理特点。方法观察分析2例硬化性上皮样纤维肉瘤病理学改变和免疫组织化学表现。结果硬化性上皮样纤维肉瘤以小圆形、卵圆形上皮样细胞为特征性改变,间质由大量的胶原纤维构成,免疫组化Vimentin阳性、EMA、S-100可有阳性表达,SMA、CD34、CK均不表达。结论硬化性上皮样纤维肉瘤是低度恶性纤维肉瘤,以局部复发为主,可以发生转移。
Objective To investigate the pathological features of sclerosing epithelioid fibrosarcoma. Methods Two cases of sclerosing epithelial fibrosarcoma were observed and analyzed for pathological changes and immunohistochemistry. Results Sclerotic epithelioid fibrosarcoma was characterized by small round oval epithelioid cells. The stroma consisted of a large number of collagen fibers. Immunohistochemistry showed that Vimentin was positive, EMA and S-100 were positive, while SMA, CD34, CK are not expressed. Conclusions Sclerotic epithelioid fibrosarcoma is a low-grade fibrosarcoma, which is mainly local recurrence and may metastasize.