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目的寻找脑缺血后的最佳溶栓时机和溶栓方法，提高急性脑血管病的治疗效果。方法本组实验应用不完全脑缺血模型，再灌流的同时应用自由基清除剂，并于缺血后１２ｈ和２４ｈ取材，在光镜和电镜下观察。结果不完全脑缺血持续组与不完全脑缺血３ｈ、６ｈ再灌流三组均有血管扩张，神经细胞部分溶解，线粒体部分溶解。但是，再灌流组损害较不灌流组明显减轻。结论再灌流时间应限制在缺血６ｈ以内，再灌流前应用自由基清除剂可以改善预后。
Objective To find the optimal thrombolysis timing and thrombolysis after cerebral ischemia to improve the therapeutic effect of acute cerebrovascular disease. Methods In this experiment, incomplete cerebral ischemia model was applied. At the same time, free radical scavenger was applied to reperfusion, and harvested at 12 h and 24 h after ischemia, observed under light and electron microscope. Results In the incomplete cerebral ischemia group and the incomplete cerebral ischemia group 3h and 6h, all the three groups had vasodilatation, nerve cells partially dissolved and mitochondria partially dissolved. However, the damage in the reperfusion group was significantly reduced compared with the non-perfusion group. Conclusion The reperfusion time should be limited within 6 hours after ischemia, and the application of free radical scavenger before reperfusion can improve the prognosis.