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Objective:Obstructive jaundice promotes bacterial translocation from the gut,the process of which remains unclear.Methods:Obstructive jaundice was induced under sterile conditions by laparotomy,ligation and transection of common bile duct.Seven days after induction,animals were killed for transmission electron microscopy.Results:The direct invasion of the enterocytes by enteric bacteria was observed.Phagocytes (predominately macrophages) bearing bacteria were found in the intestinal lumen,in the fissure between the enterocytes,in the lamina propria,submucosa and subepithelial lymphatics.Conclusions:Enteric bacteria aggressively enter into the enterocytes rather than between them by a process different from classical phagocytosis.Meanwhile,macrophages appear to act as “carrier”of bacteria in their translocation.The lymphatic-systemic circulation might be a main route of bacterial transloscation to the extraintestinal sites.
Objective: Obstructive jaundice promotes bacterial translocation from the gut, the process of which remains unclear. Methods: Obstructive jaundice was induced under sterile conditions by laparotomy, ligation and transection of common bile duct. Seven days after induction, animals were killed for transmission electron microscopy . Results: The direct invasion of the enterocytes by enteric bacteria was observed. Phagocytes (predominately macrophages) bearing bacteria were found in the intestinal lumen, in the fissure between the enterocytes, in the lamina propria, submucosa and subepithelial lymphatics. Conclusions: Enteric bacteria aggressively enter into the enterocytes rather than between by a process different from classical phagocytosis .Meanwhile, macrophages appear to act as “carrier” of bacteria in their translocation.The lymphatic-systemic circulation of be a main route of bacterial transloscation to the extraintestinal sites .