肾移植后高血压常见,尤其是应用环孢素治疗的病人.钙拮抗剂可减低环孢素对肾脏血液动力学的影响,但其长期效果尚不清楚。为评价尼群地平对肾移植后应用环孢素治疗病人肾功能的影响,研究者进行了随机、双盲、安慰剂对照、多中心试验。4个中心的253例肾移植后6～12周的病人纳入研 Hypertension after renal transplantation is common, especially in patients treated with cyclosporine, and calcium antagonists reduce the effects of cyclosporine on renal hemodynamics, but its long-term efficacy is not known. To evaluate the effect of nitrendipine on renal function in patients treated with cyclosporine after kidney transplantation, the investigators conducted a randomized, double-blind, placebo-controlled, multicentre trial. 253 patients of 4 centers aged 6 to 12 weeks after renal transplantation were included in the study