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目的调查一起肾综合征出血热(HFRS)疫情发生的原因,为预防控制疫情提供依据。方法采用现场流行病学调查方法,调查死者的亲属及相关医务人员,查阅临床资料,开展宿主动物的相关调查、密切接触者和高危人群的血清学检测。结果2008年7月湖南省道县报告2例HFRS死亡病例,经湖南省疾病预防控制中心(CDC)检测死者的血清样品,IgM抗体阳性,确诊为HFRS感染。检测病例工作场所及居住地周围的宿主动物鼠肺44份,汉坦病毒感染率为6.82%。检测患者同事血清标本14份,IgM抗体均为阴性。结论本次调查结果认为,HFRS疫情传染来源可能是由于洪水后鼠类迁移至室内引起人的感染,应采取灭鼠和免疫人群相结合的综合防制措施,更好地预防和控制HFRS。
Objective To investigate the causes of an outbreak of hemorrhagic fever with renal syndrome (HFRS) and provide a basis for prevention and control of the outbreak. Methods The method of field epidemiology was used to investigate the relatives and related medical staff of the deceased and to investigate the clinical data, to carry out relevant investigations on host animals, serological detection of close contacts and high-risk groups. Results Two deaths from HFRS were reported in Daoxian County, Hunan Province in July 2008. Serum samples from deceased persons were detected by CDC in Hunan Province. IgM antibodies were positive and confirmed as HFRS infection. Forty-four mouse lungs were detected in the workplace and living area of the patients, with a Hantavirus infection rate of 6.82%. Serum specimens of patients were detected in 14 copies, IgM antibodies were negative. Conclusion The findings of this investigation suggest that the source of HFRS epidemic may be due to the migration of rodents into humans in the interior after floods. Comprehensive prevention and control measures should be taken to eliminate and control HFRS.