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目的探究老年2型糖尿病患者甲状腺激素水平变化及其临床意义。方法 100例老年2型糖尿病患者,根据病情程度分为轻症组(68例)与重症组(32例),并选取同期健康体检50例老年人作为对照组,对所有研究对象进行胰岛素相关指标(空腹血糖、空腹胰岛素、空腹C肽、糖化血红蛋白)与甲状腺相关指标[甲状腺素(T4)、三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、反三碘甲状腺原氨酸(r T3)]水平检测并作对比分析。结果重症组患者空腹血糖、空腹胰岛素、空腹C肽与糖化血红蛋白水平均明显高于轻症组及对照组,差异具有统计学意义(P<0.05);轻症组患者空腹血糖(10.3±2.9)mmol/L、空腹C肽(530.6±115.7)mmol/L与糖化血红蛋白水平(7.2±0.9)%均明显高于对照组(5.4±0.7)mmol/L、(380.3±96.7)mmol/L、(5.1±0.4)%,差异具有统计学意义(P<0.05);轻症组患者空腹胰岛素水平(40.2±13.6)mmol/L与对照组(38.1±12.3)mmol/L比较差异无统计学意义(P>0.05)。三组研究对象T3、T4、TSH水平比较差异无统计学意义(P>0.05);重症组患者r T3水平明显高于对照组与轻症组,FT3、FT4明显低于对照组与轻症组,差异具有统计学意义(P<0.05);轻症组患者FT3水平明显低于对照组,差异具有统计学意义(P<0.05)。结论老年2型糖尿病患者甲状腺激素水平变化情况可以反映出患者病情严重程度,定期对甲状腺激素水平检测,可以对病情进行评估,并为该病的治疗与预后提供有效的指导,具有重要的价值与意义。
Objective To investigate the changes of thyroid hormone levels in elderly patients with type 2 diabetes mellitus and its clinical significance. Methods A total of 100 elderly patients with type 2 diabetes mellitus were divided into mild group (68 cases) and severe group (32 cases) according to the severity of the disease. Fifty elderly people in the same period were selected as the control group. All the subjects were enrolled in the study. (Fasting blood glucose, fasting insulin, fasting C-peptide, glycosylated hemoglobin) and thyroid related indicators [thyroid hormone (T4), triiodothyronine (T3), free triiodothyronine (FT3), free thyroxine FT4), thyrotropin (TSH), anti-triiodothyronine (rT3)] levels were detected and compared. Results The levels of fasting blood glucose, fasting insulin, fasting C-peptide and HbA1c in severe group were significantly higher than those in mild group and control group (P <0.05). The fasting blood glucose (FBG) mmol / L, fasting C peptide (530.6 ± 115.7) mmol / L and HbA1c (7.2 ± 0.9)% were significantly higher than those in the control group (5.4 ± 0.7 mmol / L and 380.3 ± 96.7 mmol / 5.1 ± 0.4)%, the difference was statistically significant (P <0.05). There was no significant difference in fasting insulin (40.2 ± 13.6) mmol / L between the mild group and the control group (38.1 ± 12.3 mmol / L) P> 0.05). The levels of T3, T4 and TSH in the three groups were not significantly different (P> 0.05). The levels of rT3 in the severe group were significantly higher than those in the control group and the mild group, FT3 and FT4 were significantly lower than those in the control group and the mild group , The difference was statistically significant (P <0.05); FT3 levels in patients with mild disease were significantly lower than those in the control group, the difference was statistically significant (P <0.05). Conclusions The changes of thyroid hormone levels in elderly patients with type 2 diabetes mellitus can reflect the severity of the disease. Regular thyroid hormone levels can be assessed and the disease can be assessed and effectively guided by the treatment and prognosis of the disease, which is of great value. significance.