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自从人们认识到泪膜的稳定性可使干燥性角结膜炎患者的症状得到改善,泪膜破裂时间(BUT)便成为在短期内评定某项治疗疗效的最简单的指标。然而,传统的BUT检查,实际观察的只是荧光素本身的变化,而所研究的滴眼剂的效果,还可以受其影响而发生改变。因此,只有选择对泪膜无侵害性的非荧光素染色检查,反复测定泪膜的稳定性,才能得知所研究的滴眼剂的真正效果如何。
Since it has been recognized that the stability of the tear film improves the symptoms of patients with keratoconjunctivitis sicca, the tear film break-up time (BUT) becomes the simplest measure of the efficacy of a treatment in a short period of time. However, the traditional BUT test, the actual observation is only the change of fluorescein itself, and the effect of the eye drops studied, but also can be affected by changes. Therefore, only by choosing non-invasive non-fluorescein staining of the tear film and by repeatedly measuring the stability of the tear film, can one be aware of the true effect of the eye drop studied.