AIM: To examine the expression of E-cadherin, β-catenin, γ-catenin, VEGF, and p53 in 39 patients with hepatic metastasis from colorectal cancer immunohistochemically. METHODS: The patients were divided into two groups: those (n=16) who had no chemotherapy for at least 6 mo before the liver resections and those (n=23) who were treated with chemotherapy before liver resections. A score from 0 to 3 was given for the number of positive cells and from 0 to 3 for the intensity of staining in these cells, in both healthy and metastatic liver parenchyma. RESULTS: No significant differences in the expression of E-cadherin, β-and γ-catenin, VEGF and p53, could be observed between patients who received and did not receive chemotherapy, in both normal and metastatic liver parenchyma. CONCLUSION: Despite the assumption that chemotherapy had an effect on liver metastasis, no influences were noticed immunohistochemically. AIM: To examine the expression of E-cadherin, β-catenin, γ-catenin, VEGF, and p53 in 39 patients with hepatic metastasis from colorectal cancer immunohistochemically. METHODS: The patients were divided into two groups: those (n = 16) who had no chemotherapy for at least 6 months before the liver resections and those (n = 23) who were treated with chemotherapy before liver resections. A score from 0 to 3 was given for the number of positive cells and from 0 to 3 for the intensity of staining in these cells, in both healthy and metastatic liver parenchyma. RESULTS: No significant differences in the expression of E-cadherin, β-and γ-catenin, VEGF and p53, could be observed between patients who received and did not receive chemotherapy, in both normal and metastatic liver parenchyma. CONCLUSION: Despite the assumption that the chemotherapy had an effect on liver metastasis, no interference were noticed immunohistochemically.