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目的观察丙酸氟替卡松联合孟鲁司特治疗儿童咳嗽变异性哮喘的临床疗效。方法选取2011年8月-2012年4月在潍坊市妇幼保健院儿科就诊的70例儿童咳嗽变异性哮喘(CVA)患儿作为研究对象,随机分为2组,对照组30例,治疗组40例。对照组应用丙酸氟替卡松气雾剂吸入治疗,治疗组在此基础上加用孟鲁司特口服治疗。两组总疗程均为12周。结果治疗组咳嗽缓解、消失时间均比对照组缩短,差异有统计学意义(P<0.05)。疗程结束后均随访6个月,治疗组复发2例,对照组复发7例,复发率治疗组明显低于对照组(P<0.05)。结论丙酸氟替卡松联合孟鲁司特治疗儿童咳嗽变异性哮喘,其疗效表现出较好的协同作用。
Objective To observe the clinical efficacy of fluticasone propionate montelukast in children with cough variant asthma. Methods Seventy children with cough variant asthma (CVA) from August 2011 to April 2012 in Weifang Maternal and Child Health Care Hospital were randomly divided into 2 groups: control group (30 cases), treatment group 40 example. The control group was treated with fluticasone propionate aerosol inhalation, and the treatment group was treated with montelukast oral. The two groups were treated for 12 weeks. Results The treatment group cough relief, disappear time than the control group shortened, the difference was statistically significant (P <0.05). After the course of treatment were followed up for 6 months, the treatment group relapsed in 2 cases, the control group relapsed in 7 cases, the recurrence rate of the treatment group was significantly lower than the control group (P <0.05). Conclusion The combination of fluticasone propionate and montelukast in children with cough variant asthma has a good synergistic effect.