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目的比较和观察通心络胶囊联合阿托伐他汀应用与单用对原发性高血压病人颈动脉内膜中层厚度(intercellular membrane thickness,IMT)的影响及临床意义。方法选择91例Ⅰ、Ⅱ级高血压且血脂正常病人,随机分为两组,A组应用通心络胶囊每次四粒(0.38g/粒),每日2次;B组应用通心络胶囊每次四粒(0.38g/粒,每日2次,合用阿托伐他汀10mg,每日1次,治疗12周。治疗前、后超声测定IMT、总胆固醇(TC)、低密度脂蛋白C(LDL-C)三酰甘油(TG)。结果相对于治疗前,治疗后2周血压显著下降(t=12.13～23.10,P<0.01),12周后血压趋于稳定,两组的降压幅度无显著差别(t=0.29～1.51,P>0.05)。与治疗前比较,A组IMT显著降低(t=2.10、2.71,P<0.05),TC、LDL-C、TG无显著改变(t=0.21～0.63,P>0.05),B组TC、LDL-C、TG、IMT均显著降低(t=2.79～14.12,P<0.01),两组比较有显著差异(t=2.51～7.38,P<0.05)。结论通心络胶囊联合阿托伐他汀应用与单用比较,逆转原发性高血压病人颈动脉IMT的效果显著。
Objective To compare and observe the effect of Tongxinluo capsule combined with atorvastatin and carotid artery on the carotid artery intima-media thickness (IMT) in patients with essential hypertension and its clinical significance. Methods Ninety-one patients with grade I and II hypertension and normal blood lipids were randomly divided into two groups. Group A received Tongxinluo capsule four times a day (0.38g / capsule) twice a day. Group B received Tongxinluo Capsule each time four (0.38g / tablets, 2 times a day, combined with atorvastatin 10mg, 1 day, for 12 weeks before and after treatment, ultrasound determination of IMT, total cholesterol (TC), low density lipoprotein C (LDL-C) triglyceride (TG) .Results Before treatment, the blood pressure decreased significantly 2 weeks after treatment (t = 12.13-23.10, P <0.01), and the blood pressure tended to be stable after 12 weeks There was no significant difference in pressure amplitude (t = 0.29 ~ 1.51, P> 0.05). Compared with before treatment, IMT in group A was significantly lower (t = 2.10,2.71, P < t = 0.21-0.63, P> 0.05). The levels of TC, LDL-C, TG and IMT in group B were significantly decreased (t = 2.79-14.12, P <0.01) P <0.05) .Conclusion The effect of Tongxinluo capsule combined with atorvastatin on the carotid IMT in patients with essential hypertension is significant compared with the single use.