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应用丙酸杆菌和内毒素引起肝坏死动物模型对前列腺素Ｅ＿１（ＰＧＥ＿１）抑制肝坏死发生作用及其机理进行了研究。结果：①ＰＧＥ＿１投给组的动物生存率为９０％较对照组（１７％）明显增高。肝组织学检查未发现肝细胞坏死；②当ＰＧＥ＿１添加后。丙酸杆菌处理小白鼠肝内枯否细胞培养上清液中的肿瘤坏死因子（ＴＮＦ）、分泌型白细胞介素１（ＳＩＬ－１）和膜型白细胞介素１（ｍＩＬ－１）活性受到抑制，其抑制程度随ＰＧＥ＿１浓度增加而增大。上述结果说明：ＰＧＥ＿１可以抑制肝坏死的发生，其作用机制可能与抑制ＴＮＦ、ＳＩＬ－１和ｍＩＬ－１活性有关。
The animal model of hepatic necrosis caused by propionibacteria and endotoxin was used to study the effect and mechanism of prostaglandin E_1 (PGE_1) on hepatic necrosis. Results: ① The survival rate of animals in the PGE_1 group was 90% higher than that in the control group (17%). Hepatic necrosis was not found in liver histology; ② When PGE_1 was added. The activities of tumor necrosis factor (TNF), secretory interleukin-1 (IL-1) and membrane-type interleukin-1 (mIL-1) in the culture supernatant of Kupffer cell were inhibited by propionibacterium , The inhibition increased with the increase of PGE_1 concentration. The above results indicate that PGE 1 can inhibit the occurrence of hepatic necrosis and its mechanism may be related to the inhibition of TNF, SIL-1 and mIL-1 activity.