【摘 要】
：
A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,
【机 构】
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Department of Chemistry,School of Sciences,Hakim Sabzevari University,
论文部分内容阅读
A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple,effective,and environmentally friendly was shown.Ammonium dihydrogen phosphate(NH4H2PO4) was used as a non-toxic,inexpensive,and easily available catalyst.The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2- (1H) -ones under solvent-free conditions that is simple, effective, andghansible friendly was shown as. Ammonium dihydrogen phosphate (NH4H2PO4) was used as a non-toxic, inexpensive, and easily available catalyst. The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
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