三氮唑核苷(Ribavirin)是一种人工合成的三氮唑核苷,有治疗拉沙(Lassa)热和某些病毒性呼吸道感染的价值,在1972年首次合成,具有独特的广谱抗病毒能力。在实验室内发现它能抑制许多RNA和DNA病毒,包括A、B型流感病毒,1、2和3型副流感病毒及呼吸道合胞病毒(RSV)和可能的冠状病毒等,其抗病毒作用表现在复制环的各点上,但一般累及核苷酸池的变化和干扰脒基化步骤。三氮唑核苷是低细胞毒性药物,人们能很好地耐 Ribavirin, a synthetic ribavirin, is valuable for the treatment of fever and certain viral respiratory infections of Lassa and was first synthesized in 1972 with a unique broad-spectrum anti-viral Viral ability. It has been found in laboratories that it inhibits many RNA and DNA viruses, including influenza A and B viruses, parainfluenza virus types 1, 2 and 3, respiratory syncytial virus (RSV) and possibly coronavirus, which have antiviral effects It appears at every point of the replication loop, but generally involves changes in nucleotide pools and disrupts the amidation step. Ribavirin is a low-cytotoxic drug that people are well tolerated