顺铂(cisplatin)为最有效的癌症化疗剂之一,可治疗多种类型的肿瘤,但有严重的副作用如肾毒性。前文证实了十全大补汤可预防顺铂的肾毒性和骨髓毒性,而且不影响顺铂的抗癌作用,本文进一步研究十全大补汤对顺铂诱导毒性的影响,同时,观察十全大补汤在高剂量时能否减轻或预防顺铂对小鼠的致死毒性。 实验方法:选取5周龄雄性ddY小鼠, Cisplatin is one of the most effective cancer chemotherapeutic agents and can treat many types of tumors but has serious side effects such as nephrotoxicity. The foregoing confirmed that Shiquan Dabu Tang can prevent the nephrotoxicity and bone marrow toxicity of cisplatin, and does not affect the anticancer effect of cisplatin. This article further studied the effect of Shiquan Dabu Tang on cisplatin-induced toxicity, and at the same time, observed Shiquan Whether Dabu Decoction can reduce or prevent lethal toxicity of cisplatin in mice at high doses. Experimental method: 5-week-old male ddY mice were selected.