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Objective:To study the relationship of the expression of P-glycoprotein (P-gp) in hepatocellular carcinoma (HCC) to invasion and intrahepatic metastasis.Methods: Surgical samples of 47 patients with HCC were investigated using immunohistochemical method in combination with computer-imaging analytic technique.Results: In HCC, anti-P-gp immunostaining was mainly localized in the cellular membrane. A significantly higher positive percentage of P-gp expression was observed in HCC tissues than normal liver tissues (P＜0.01). HCCs with intrahepatic metastasis had a significantly higher Pgp expression level than those without intrahepatic metastasis (P＜0.01). The expression level of P-gp in HCCs with invasion was significantly higher than that in HCCs without invasion (P＜0.05). Conclusion: P-gp may play an important role in the invasion and intrahepatic metastasis of HCC. P-gp expression level in tumor correlates the progression of HCC.