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目的研究内皮素受体拮抗剂阿魏酸钠(SF)对慢性肾功能衰竭(CRF)患者血清内皮素(ET)、一氧化氮(NO)及肾功能的影响。方法应用常规治疗加注射SF治疗CRF患者,观察治疗前后血清ET、NO及血肌酐(Scr)、尿素氮(BUN)改变,并与常规治疗组、健康对照组相比较。结果常规治疗组与SF治疗组治疗前血清ET、NO水平明显高于健康对照组,差异有统计学意义(P<0.05),SF治疗后,其血清ET、NO、Scr、BUN均显著下降,与治疗前相比较,差异有统计学意义(P<0.05)。结论SF能够降低CRF患者血清ET、NO水平,改善肾功能,延缓CRF进展。
Objective To investigate the effects of endothelin receptor antagonist sodium ferulate (SF) on serum endothelin (ET), nitric oxide (NO) and renal function in patients with chronic renal failure (CRF). Methods The patients with CRF were treated with routine treatment and SF injection. The changes of serum ET, NO, Scr and BUN were observed before and after treatment, and compared with those of routine treatment group and healthy control group. Results The levels of serum ET, NO in SF group and SF group before treatment were significantly higher than those in healthy group (P <0.05). After treatment with SF, the levels of ET, NO, Scr and BUN were significantly decreased, Compared with before treatment, the difference was statistically significant (P <0.05). Conclusion SF can reduce serum ET and NO levels, improve renal function and delay the progression of CRF in CRF patients.