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目的通过检测完全性葡萄胎(CM)、部分性葡萄胎(PM)及水肿流产胎(HA)中p57、GLUT-1的表达,探讨其表达的临床意义。方法应用免疫组织化学方法检测CM、PM及HA组织中p57、GLUT-1的表达。结果 1.p57、GLUT-1在CM中阳性表达率为10%、83.3%;在PM中阳性表达率为86.7%、23.3%;在HA中阳性表达率为90%、0.0%。2.p57、GLUT-1在CM与PM之间的阳性表达率存在显著性差异(P<0.05),在CM与HA中的阳性表达率也存在显著性差异(P<0.05),在PM与HA中阳性表达率无显著性差异(P>0.05)。结论 1.同时检测p57、GLUT-1可更好的鉴别CM、PM及HA。2.p57、GLUT-1可能参与了葡萄胎的恶变。
Objective To investigate the clinical significance of the expression of p57 and GLUT-1 in complete mohyma (CM), partial moles (PM) and edema and abortion (HA). Methods Immunohistochemistry was used to detect the expression of p57 and GLUT-1 in CM, PM and HA tissues. Results 1. The positive rates of p57 and GLUT-1 in CM were 10% and 83.3%, respectively. The positive rates in PM were 86.7% and 23.3%, respectively. The positive rates of GLUT-1 in CM were 90% and 0.0% respectively. There was significant difference (P <0.05) in the expression of p57, GLUT-1 between CM and PM, there was significant difference between CM and HA (P <0.05) There was no significant difference in the positive expression rate of HA (P> 0.05). Conclusions 1. Simultaneous detection of p57 and GLUT-1 can better identify CM, PM and HA. 2.p57, GLUT-1 may be involved in the mole of malignant transformation.