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目的 观察大鼠帕金森综合症模型脑的黑质、尾状核及中缝核神经元超微结构变化。方法 应用透射电镜。结果 上述核团神经元的超微结构均发生病理性改变 :神经细胞核膜皱缩 ,核膜凹凸不整 ,并有局部断裂 ;线粒体变性 ,基质浓度降低及空泡化 ;粗面内质网和高尔基复合体囊腔扩张变性 ;大量初级溶酶体及脂褐素集聚 ;出现了髓样体和多泡体等变性结构。结论 黑质、尾状核及中缝核神经元超微结构的病理性变化从而导致纹状体 黑质 纹状体锥体外路系环路功能障碍 ,是引发帕金森氏综合症的结构基础。
Objective To observe the ultrastructural changes of the neurons in the substantia nigra, caudate nucleus and mesentery nuclei in the Parkinson’s disease rat model. Methods Using transmission electron microscopy. Results The ultrastructures of neurons in the nuclei were all pathologically altered. The nucleus of the nerve cells collapsed, the nucleus was irregular, with local rupture. Mitochondrial degeneration, decreased matrix concentration and vacuolization. The rough endoplasmic reticulum and Golgi Complex cystic dilatation degeneration; a large number of primary lysosomes and lipofuscin aggregation; emergence of myeloid and multivesia and other denatured structure. Conclusion The pathological changes of the ultrastructure of the substantia nigra, caudate nucleus and meso-nucleus lead to extrapyramidal loop dysfunction in the substantia nigrostriatum, which is the structural basis of Parkinson’s disease.