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目的 :探讨三七对烫伤大鼠肝组织脂质过氧化的影响及保护作用。方法 :采用大鼠 4 0 %体表面积 (TB SA)Ⅲ度烫伤模型 ,通过检测大鼠严重烫伤后肝组织内丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GSH -PX)和超氧化物歧化酶 (SOD)的改变 ,观察三七对烫伤大鼠的保护作用。结果 :4 0 %TBSAⅢ度烫伤后大鼠肝组织内MDA显著升高 ,GSH -PX和SOD活力显著降低 ,三七治疗组大鼠肝组织内MDA含量显著降低 ,GSH -PX和SOD活力显著升高 ,与单烫伤组比较各指标均有显著性差异。结论 :烫伤后肝组织内脂质过氧化增强 ,抗氧化能力减弱 ,三七具有较强的抗氧化、抗自由基损伤的保护作用。
Objective : To investigate the effect and protective effect of Panax notoginseng on lipid peroxidation in liver tissue of scalded rats. METHODS: Rats were treated with a 40% body surface area (TB SA) III-degree scald model to detect malondialdehyde (MDA), glutathione peroxidase (GSH-PX), and hepatic tissue in rats after severe scald. The change of superoxide dismutase (SOD) was observed to observe the protective effect of Panax notoginseng on scald rats. RESULTS: MDA in the hepatic tissue was significantly increased in 40% TBSA scald, and the activity of GSH-PX and SOD was significantly reduced. The MDA content in the liver tissue of the group treated with Panax notoginseng was significantly decreased, and the activity of GSH-PX and SOD was significantly increased. High, compared with the single burn group, there were significant differences in each index. Conclusion : The lipid peroxidation in liver tissue is increased after burns, and the antioxidant capacity is weakened. Panax notoginseng has strong antioxidant and anti-free radical protection.