【摘 要】
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Dear Editor,nABCD1,a member of the subfamily D of ABC transporters,participates in the transport of various fatty acid-CoA derivatives or very long-chain fatty acids (VLCFA) into the peroxisome and is essential for peroxisomal metabolism and lipid homeost
【机 构】
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Department of Molecular Genetics,University of Texas Southwestern Medical Center,Dallas,TX,USA;Depar
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Dear Editor,nABCD1,a member of the subfamily D of ABC transporters,participates in the transport of various fatty acid-CoA derivatives or very long-chain fatty acids (VLCFA) into the peroxisome and is essential for peroxisomal metabolism and lipid homeostasis.1 Dysfunction of human ABCD1 is associated with neurodegenera-tive diseases,including X-linked adrenoleukodystrophy (X-ALD).1 The molecular basis of substrate recognition and transport by human ABCD1 remains unknown.To date,four ABCD members have been identified in mammals.1 As exporters,ABCD1-3 transport fatty acid-CoA derivatives or VLCFA from the cytosol into peroxisomes for β-oxidation with substrate preferences.
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