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目的判断与R et、粘蛋白-1(M uc in-1)和半乳糖凝集素-3(G a lectin-3)蛋白识别的相关因素及影响甲状腺肿块复发的可能因素。方法观察R et、M uc in-1(MUC 1)和G a lectin-3(G a l-3)表达与甲状腺滤泡源性肿瘤相关指标的关系,并与随访资料相结合,分析甲状腺肿瘤有关的生物学行为。结果①运用多因素逐步log istic回归分析法,分别得出R et、MUC 1、G a l-3表达的log istic回归方程,结果包膜存在、最大直径是R et表达的抑制因素,包膜侵犯与双侧性对R et表达有促进作用。合并病变、包膜存在是MUC 1表达的抑制因素,包膜存在也是G a l-3表达的抑制因素,包膜侵犯对MUC 1和G a l-3表达有促进作用。②预后分析的Cox比例风险函数模型可知:有包膜比无包膜或包膜不完整者在某时刻复发的相对危险度为0.126,即复发的可能性降低了87.4%;病程每增加一个等级,在某时刻复发的相对危险度为2.701,即复发的可能性增加了1.701倍。结论①包膜存在与甲状腺肿瘤不或低表达R et、MUC 1和G a l-3关联;恶性肿瘤的包膜侵犯与恶性标志物表达密切关联;囊性变与MUC 1和R et的阴性表达有关;双侧性同一病变者R et表达的可能性增高;腺体外浸润、淋巴结转移者表达R et、MUC 1和G a l-3的机率增高,其关联性表明三种标志物能反映恶性肿瘤的生物学行为。②复发有关因素中有包膜者,不易复发;而及早诊治甲状腺病变,其术后复发可大大降低。
Objective To determine the related factors of R et, M uc in-1 and G a lectin-3 proteins and the possible factors that influence the recurrence of thyroid mass. Methods The relationship between the expression of R et, M uc in-1 (MUC 1) and G a lectin-3 (G a l-3) and follicular-derived thyroid tumors was analyzed. The thyroid tumor Related biological behavior. Results (1) Logistic regression equation of R et, MUC 1 and G a l-3 expression was obtained by logistic regression analysis with multiple factors step by step. The results showed that the maximum diameter was the inhibitory factor of R et, Invasion and bilateral sex have a positive effect on R et expression. The coexistence of lesions and the presence of the envelope is a suppressor of the expression of MUC 1, and the presence of the envelope is also an inhibitory factor for the expression of G a l-3. Envelope invasion contributes to the expression of MUC 1 and G a l -3. ② Cox proportional hazard function model of prognostic analysis shows that: the relative risk of recurrence of the non-enveloped or non-enveloped patients at a time is 0.126, that is, the probability of recurrence is reduced by 87.4%; for each additional course of disease , The relative risk of recurrence at a time was 2.701, that is, the likelihood of recurrence increased by 1.701 times. Conclusions ① There is a correlation between the presence of envelop and the expression of R et, MUC 1 and G a l-3 in thyroid neoplasms. The invasion of malignant tumor is closely related to the expression of malignant markers. The cystic changes are not associated with the negative expression of MUC 1 and R et The expression of R et was higher in patients with the same bilateral lesion; the probability of R et, MUC 1 and G a l-3 expression in extra-gland infiltration and lymph node metastasis was increased, and the correlation showed that the three markers Reflect the biological behavior of malignant tumors. ② recurrence of the envelope in those factors, not easy to relapse; and early diagnosis and treatment of thyroid disease, the recurrence can be greatly reduced.