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5. Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α （TNF-α） conjugate f

Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α （TNF-α） conjugate f

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：zhoujhipanel

【摘 要】

：

To design a releasable PEGylated TNF-α(rPEG-TNF-α ), a cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified TNF- (PEG-

【作 者】

：

DAI ChuanYun FU Ya CHEN ShaoCh 

【机 构】

：

DepartmentofChemistryandChemicalEngineering,DepartmentofBiologicalandChemicalEngineering,Instituteof

【出 处】

：

中国科学：生命科学英文版

【发表日期】

：

2013年1期

【关键词】

：

肿瘤坏死因子 聚乙二醇化 抗肿瘤治疗 修饰 组织蛋白酶B TNF-Α 评价 制备 tumor necrosis factor-α  releasable PEG 

【基金项目】

：

This work was supported by the National Natural Science Foundation of China （30701055）, in part by the China Postdoctoral Science Foundation （20070410029）, and in part by the Foundation of Innovation

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To design a releasable PEGylated TNF-α(rPEG-TNF-α ), a cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified TNF- (PEG-TNF- ), facilitating its clinical use for anti-tumor therapy. Comparative pharmaco- kinetic and p

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