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目的 探讨ABO血型与冠状动脉(简称冠脉)钙化(CAC)的相关性.方法 选取在我中心行冠脉CT检查的患者301例,根据CAC评分(CACS)分为非CAC组(CACS=0分)197例和CAC组(CACS＞0分)104例.收集两组患者的年龄、BMI、冠心病家族史等一般资料,检测其血常规、血脂、超敏C反应蛋白(hs-CRP)和ABO血型并进行比较,采用单因素和多因素回归分析上述指标与CACS的相关性.结果 两组患者性别、BMI及高血压、糖尿病患者所占比例的差异均无统计学意义(P＞0.05);CAC组年龄、冠心病及有冠心病家族史患者所占比例均高于非CAC组,吸烟和饮酒患者所占比例低于非CAC组(P＜0.05).两组之间甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、WBC以及载脂蛋白A(ApoA)比较,差异均无统计学意义(P＞0.05).CAC组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP和A型血的比例均高于非CAC组,O型血的比例低于非CAC组(P＜0.05).两组间B型血和AB型血患者所占比例的差异均无统计学意义(P＞0.05).单因素回归分析结果显示,年龄、TC、LDL-C、hs-CRP、A型血和O型血与CACS有相关性(P＜0.05);多因素回归分析结果显示,年龄、TC、hs-CRP和A型血是CAC的独立危险因素(P＜0.05).结论 ABO血型与CAC之间具有一定的相关性,A型血可能是CAC的独立危险因素.“,”Objective To explore the correlation between ABO blood types and coronary artery calcium(CAC).Methods According to CAC scores (CACS),three hundred and one patients receiving CT examination in our division were divided into non-CAC group(CACS =0) with 197 patients and CAC group (CACS ＞ 0) with 104 patients.Baseline characteristics such as age,BMI and family history of coronary artery disease (CAD) were collected and laboratory parameters such as blood routine,lipid parameters,high sensitivity C-reactive protein (hs-CRP) and ABO blood types were tested.All the parameters mentioned above were compared between the two groups.The correlation between these clinical parameters and CACS were analyzed using univariate and multivariate regression model.Results There were no significant differences of gender,BMI and the ratios of hypertension and diabetes patients between the two groups(P ＞0.05).Age and the ratios of CAD and family history of CAD of CAC group were higher than those in non-CAD group,and the ratio of smoking and alcohol taking were lower than that in non-CAD group (P ＜ 0.05).There were no significant differences of triglycerides (TG),high density lipoprotein cholesterol(HDL-C),WBC and apolipoprotein (Apo) A between the two groups (P ＞ 0.05).Total cholesterol(TC),low density lipoprotein cholesterol (LDL-C),hs-CRP and the ratio of A blood type in CAC group were higher,and the ratio of O blood type was lower than non-CAC group (P ＜ 0.05).There were no significant differences of the ratio of B and AB blood type between two groups(P ＞0.05).Age,TC,LDL-C,hs-CRP,A blood type and O blood type were associated with CACS(P ＜ 0.05) in univariate regression analysis.Age,TC,hs-CRP and A blood type were independent risk factors of CAC (P ＜ 0.05) in multivariate regression analysis.Conclusion ABO blood types were associated with CAC and A blood type may be one of the independent risk factors of CAC.