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点击化学(Click chemistry)自从2001年被Sharpless提出之后,得到了飞速的发展.而Cu(I)催化的叠氮-炔之间的环加成(Cue-AAC)反应作为点击反应的典型代表,已广泛地应用于新材料的制备、药物的合成以及催化剂载体之中.但是在反应过程中使用Cu(I)催化剂,导致产品易被金属铜盐污染,从而使该反应在生物医药等应用领域受到限制.基于氧化腈的点击反应作为一类新型的点击反应,其不仅仅可以与炔、烯进行1,3-偶极环加成反应,还可以与腈反应.由于该反应不需要铜金属催化以及有良好的立体选择性和区域选择性等的优点,常被应用于药物的制备以及一些特定结构生物活性化合物的合成中.对基于氧化腈的点击反应最新进展进行综述.
Click chemistry has been rapidly evolving since it was proposed by Sharpless in 2001. Cu (I) catalyzed azide-alkyne cycloaddition (Cue-AAC) reaction is typical of click reaction, Has been widely used in the preparation of new materials, pharmaceutical synthesis and catalyst support.But the use of Cu (I) catalyst in the reaction process, resulting in the product easily contaminated with copper metal salts, so that the reaction in the biomedical applications As a new type of click reaction, nitrite not only can undergo 1,3-dipolar cycloaddition with alkyne and alkene, but also react with nitrile.Because the reaction does not require copper metal Catalysis, good stereoselectivity, regioselectivity, etc. It is often used in the preparation of pharmaceuticals and in the synthesis of some specific structural bioactive compounds. The recent progress of nitrile oxide-based click reactions is reviewed.