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目的探索1型糖尿病(T1DM)患儿抑郁症(MDD)的患病率及二者之间的相关性。方法选取2010年1月-2015年12月在该院内分泌科就诊的T1DM患儿201例(年龄6~12周岁),根据SDS抑郁症自评量表评分,按照有无MDD进行分组,比较两组性别、年龄、体重指数(BMI)、空腹血糖、糖化血红蛋白(Hb A1c)、病程、发病年龄、出现酮症酸中毒(DKA)次数及血清皮质醇(CORT)浓度等,并进行Logistic多因素回归分析。结果 T1DM患儿MDD的患病率为39.8%,并且T1DM合并MDD患者空腹血糖(FPG)、Hb A1c、CORT及出现DKA次数均显著高于未合并MDD患者(P<0.05)。父母文化程度为T1DM患儿患MDD的保护因素;出现DKA次数、发病年龄、Hb A1c、CORT为T1DM患儿患MDD的相关危险因素。结论T1DM患儿患MDD患病率较高,二者之间具有相关性。因此应加强对于T1DM患儿的心理健康辅导。
Objective To explore the prevalence of depression (MDD) in children with type 1 diabetes mellitus (T1DM) and the correlation between the two. Methods A total of 201 T1DM children (aged 6-12 years) were enrolled in Department of Endocrinology from January 2010 to December 2015. The patients were divided into groups according to the SDS Depression Scale and MDD or not The changes of sex, age, body mass index (BMI), fasting blood glucose, Hb A1c, duration of disease, age of onset, frequency of ketoacidosis (DKA) and serum cortisol (CORT) regression analysis. Results The prevalence of MDD in T1DM children was 39.8%, and the fasting blood glucose (FPG), Hb A1c, CORT and the number of DKA in T1DM patients with MDD were significantly higher than those without MDD (P <0.05). The educational level of parents was the protective factor of MDD in T1DM children. The incidence of DKA, age of onset, Hb A1c and CORT were related risk factors of MDD in T1DM children. Conclusion The prevalence of MDD in children with T1DM is high, and the correlation between them is significant. Therefore, mental health counseling should be strengthened for children with T1DM.