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从30个处方中制备出了一种氯化钾缓释片,并与常规片进行了质量比较。缓释片的体外、体内释放速度比常规片慢得多。缓释片对猫十二指肠的刺激性也比常规片缓和得多。测定了人体尿中氯化钾的排泄量,口服氯化钾片后2小时,常规片产生了氯化钾吸收高峰,而缓释片的吸收曲线是比较平稳的。
A potassium chloride sustained-release tablet was prepared from 30 prescriptions and compared with conventional tablets. Sustained release tablets in vitro, the body release rate much slower than conventional tablets. Sustained-release tablets also have a much more irritating effect on cat duodenum than conventional tablets. Determination of human urine urinary potassium excretion, potassium chloride tablets 2 hours after oral administration, conventional tablets produced potassium chloride absorption peak, and sustained-release tablets absorption curve is relatively stable.