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[目的]探讨人乳头瘤病毒(HPV)感染与亚洲人膀胱癌罹患之间的危险性。[方法]计算机检索Pubmed、CNKI数据库、万方数据库,同时利用文献追溯等途径收集1989年1月至2011年3月国内外公开发表的有关HPV感染与亚洲人膀胱癌患病的相关文献,同时检索相关引用文献。应用Meta分析对其进行综合评价。[结果]共31篇文献符合纳入标准,其中病例—对照研究18篇。亚洲膀胱癌患者中HPV总的感染率为35.67%(95%CI:33.43%～37.97%),其中高危型HPV感染率为34.29%(95%CI:31.77%～36.87%)。亚洲人膀胱癌患者膀胱癌组织中HPV的检出率主要受到HPV感染型别和发表年限的影响。而中国大陆膀胱癌患者中,HPV的感染率为47.27%(95%CI:44.12%～50.44%),显著高于亚洲平均水平(P<0.001)。固定效应模型计算结果显示,亚洲人中HPV感染对膀胱癌罹患关联的OR值为5.17(95%CI:3.52～7.60),且主要受到HPV感染型别的影响。[结论]亚洲人中HPV感染,尤其是高危型HPV感染,可能会增加膀胱癌罹患的危险性。
[Objective] To investigate the risk of human papillomavirus (HPV) infection in Asian patients with bladder cancer. [Methods] Pubmed, CNKI database and Wanfang database were searched by computer. At the same time, the articles about the HPV infection and the prevalence of bladder cancer in Asian people published from January 1989 to March 2011 were collected at the same time Retrieve relevant citations. Meta analysis of its comprehensive evaluation. [Results] A total of 31 articles met the inclusion criteria, of which 18 were case-control studies. The overall HPV infection rate in Asian patients with bladder cancer was 35.67% (95% CI: 33.43% -37.97%). The prevalence of high-risk HPV was 34.29% (95% CI: 31.77% -36.87%). The detection rate of HPV in bladder cancer in Asian patients with bladder cancer is mainly affected by the type of HPV infection and the number of years of publication. In mainland China, the infection rate of HPV was 47.27% (95% CI: 44.12% -50.44%), which was significantly higher than the Asian average (P <0.001). The calculated results of the fixed-effects model showed that the OR value of HPV infection in bladder cancer among Asians was 5.17 (95% CI: 3.52-7.60), and was mainly affected by the type of HPV infection. [Conclusion] HPV infection in Asians, especially high-risk HPV infection, may increase the risk of bladder cancer.