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目的了解氯沙坦和依那普利对老年心力衰竭左室容量的影响。方法选择住院老年患者108例,随机分为氯沙坦组和依那普利组,测定服药前和服药16周后超声心动图指标测量左室舒张期容量指数(LVEDVI)左室收缩期末容量指数(LVESVI)及LVEF、心率,观察临床症状和不良反应。结果氯沙坦组和依那普利组口服药物前后差异有统计学意义(P<0.05),氯沙坦组和依那普利组比较差异无统计学意义(P>0.05)。结论氯沙坦和依那普利有相似的抗心室重构作用,防止左室扩张,氯沙坦组更明显,不良反应少。
Objective To investigate the effects of losartan and enalapril on left ventricular volume in elderly patients with heart failure. Methods A total of 108 elderly patients were selected and randomly divided into losartan group and enalapril group. The left ventricular end-systolic volume index (LVEDVI) was measured before and 16 weeks after taking the echocardiography. (LVESVI) and LVEF, heart rate, observation of clinical symptoms and adverse reactions. Results Before and after oral administration of losartan and enalapril groups were statistically significant (P <0.05), losartan and enalapril groups showed no significant difference (P> 0.05). Conclusion Losartan and enalapril have similar anti-ventricular remodeling effect, preventing left ventricular dilation, losartan group more obvious, fewer adverse reactions.