目的研制复方环磷酰胺多相脂质体注射剂,用于治疗癌症,提高疗效,降低药物毒性。方法通过对复方环磷酰胺多相脂质体中免疫促进剂的筛选和附加剂对环磷酰胺包封率影响的选择确定处方组成,并选择冻融法制备。结果提高环磷酰胺多相脂质体的包封率,制剂质量稳定。结论该制剂处方组成合理,临床疗效确切,毒性副作用减小。 Objective To develop a compound cyclophosphamide multiphase liposomal injection for the treatment of cancer, improve the curative effect and reduce the toxicity of drugs. Methods Prescription compositions were determined by selection of immunostimulants in multiphasic liposomes of cyclophosphamide compound and the influence of additives on the entrapment efficiency of cyclophosphamide. The formulation was prepared by freeze-thaw method. The results improve cyclophosphamide multiphase liposome entrapment efficiency, preparation quality and stability. Conclusion The formulation prescription is reasonable, the clinical curative effect is definite, the toxic side effect is reduced.