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重症急性胰腺炎(severe acute pancreatitis,SAP)属于急性胰腺炎的特殊类型,是一种病情险恶、并发症多、病死率较高的急腹症。目前,通过禁食让胰腺充分休息的观点已经摒弃。合理的临床营养治疗已逐渐得到医护人员的认同。SAP患者由于大量的炎症介质释放(细胞因子、血小板活化因子等),使肠道的微循环产生障碍,加重肠道黏膜的损伤。而谷氨酰胺可以促进肠道黏膜的修复,保护肠道微循环内皮细胞免受氧自由基的损伤。静脉营养支持补充谷氨酰胺是有益的,但要求谷氨酰胺剂量达到0.35 g(/kg·d)。由于谷氨酰胺是纯
Severe acute pancreatitis (SAP) is a special type of acute pancreatitis, which is a kind of acute abdomen with more serious complications and more mortality. At present, the idea of having the pancreas fully rested by fasting has been abandoned. Reasonable clinical nutrition treatment has gradually been recognized by medical staff. SAP patients due to the release of a large number of inflammatory mediators (cytokines, platelet activating factor, etc.), the intestinal microcirculation disorders, aggravating intestinal mucosal injury. Glutamine can promote the repair of intestinal mucosa and protect the intestinal microcirculation endothelial cells from oxygen free radicals. Supplementation of intravenous nutritional supplementation of glutamine is beneficial, but the dose of glutamine is required to reach 0.35 g (/ kg · d). Because glutamine is pure