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目的 :探讨 PTP- BAS基因在原发性肾细胞癌组织中的表达及其与临床各病理特征的关系。 方法 :利用 Northern印迹技术检测 31例肾细胞癌及其癌旁组织中 PTP- BAS m RNA表达水平。 结果 :肾细胞癌组织的 PTP- BAS m RNA表达明显弱于相应的癌旁组织 (P<0 .0 1 ) ,肾癌细胞系 786 - O细胞呈低表达 ;肾细胞癌的 PTP- BAS m RNA表达与临床各病理特征无关。 结论 :PTP- BAS基因在肾细胞癌组织的表达降低 ,推测其可能是肾细胞癌的一个抑癌基因 ,且与肾细胞癌的发生发展有关。
Objective: To investigate the expression of PTP-BAS gene in primary renal cell carcinoma and its relationship with clinical pathological features. Methods: Northern blotting was used to detect the expression of PTP-BAS m RNA in 31 cases of renal cell carcinoma and its adjacent tissues. Results: The expression of PTP - BAS m RNA in renal cell carcinoma tissues was significantly weaker than that in the corresponding paracancerous tissues (P <0.01). The expression of PTP - BAS m RNA in 786 - O cells of renal cell carcinoma was low. RNA expression has nothing to do with the clinical pathological features. CONCLUSION: The decreased expression of PTP-BAS gene in renal cell carcinoma suggests that it may be a tumor suppressor gene in renal cell carcinoma and is associated with the occurrence and development of renal cell carcinoma.