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本文对１５２例具有同胞患肝癌家族史的原发性肝癌先证者进行分析，结果表明：该组人群ＨＢＶ感染率为８１．５８％，感染标记类型有１２种，其中６８％为抗一ＨＢｃ阳性伴ＨＢｓＡｇ和（或）抗－ＨＢｅ阳性；发病高峰年龄为３０～４９岁（占７２％）；兄弟同患肝癌（６７．１１％）显著多于兄妹、姐弟同患，更显著多于姐妹同患（Ｐ＜０．００１），但伴有母患肝癌家族史的患者女性同胞也易患肝癌（Ｐ＜０．０２５）。提示具有同胞患肝癌史、年龄３０～４９岁、尤其是抗－ＨＢｃ阳性伴ＨＢｓＡｇ和（或）抗－ＨＢｅ阳性的男性乙肝患者为肝癌患者一级亲属中原发性肝癌最易感人群，应密切关注，警惕肝癌发生。
This article analyzed 152 cases of primary liver cancer proband who had a family history of siblings with HCC. The results showed that the HBV infection rate in this group was 81.58% and there were 12 infection marker types, of which 68% were anti-HBc. Positive with HBsAg and (or) anti-HBe positive; the peak age of onset was 30 to 49 years old (72%); brothers with liver cancer (67.11%) were significantly more than brothers and sisters, siblings, more significantly more than Sisters with the same patient (P<0.001), but female siblings with a family history of maternal HCC were also susceptible to HCC (P<0.025). Patients with HBsAg and/or anti-HBe positive male HBV patients who have a history of sibling HCC history, ages of 30 to 49 years, and especially anti-HBc positive are the most susceptible to primary liver cancer among the first-degree relatives of HCC patients. Pay close attention and be alert to the occurrence of liver cancer.