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目的 了解 POAG房水内皮素与眼压有无相关关系。方法 通过放射免疫饱和分析法 (RIA )测定高眼压状态的原发性开角型青光眼 (POAG)及正常眼压的白内障患者房水内皮素 (ET)。结果 POAG组明显高于白内障组 (P <0 .0 1)。两组术前眼压比较 ,P <0 .0 1POAG眼压和 ET回归分析 ,P <0 .0 5 ,白内障组眼压与 ET回归分析 ,P >0 .0 5。结论 POAG眼压与 ET分泌有相关关系 ,眼部 ET水平的改变是机体对眼压增高产生的一种保护性应急反应 ,ET可能与 POAG发病有关。
Objective To investigate the relationship between endothelin and intraocular pressure in POAG aqueous humor. Methods Radioimmunoassay (RIA) was used to determine the aqueous humor endothelin (ET) in patients with primary open angle glaucoma (POAG) and normal intraocular pressure (IOP). Results The POAG group was significantly higher than the cataract group (P <0.01). The two groups of preoperative intraocular pressure, P <0.01 POAG intraocular pressure and ET regression analysis, P <0. 05, cataract intraocular pressure and ET regression analysis, P> 0. Conclusions The intraocular pressure (POAG) of POAG is correlated with ET secretion. The change of ocular ET level is a protective emergency response to elevated intraocular pressure. ET may be related to the pathogenesis of POAG.