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ＰＭＰＰＩ分子式中含多个－ＮＣＯ基团，对眼、皮肤等有轻微刺激和潜在致敏作用。小鼠经口ＬＤ５０为７２６６１ｍｇ／ｋｇ，表明ＰＭＰＰＩ属低毒化合物。２小时吸入染毒小鼠ＬＣ５０大于１２６９ｍｇ／ｍ３，大鼠ＬＣ５０大于５７２ｍｇ／ｍ３。亚慢性吸入染毒实验表明４４９ｍｇ／ｍ３可视为无可见作用浓度。Ａｍｅｓ、ＵＤＳ试验和小鼠骨髓微核试验表明ＰＭＰＰＩ在很高剂量时有一定致突变性。安全系数拟取１０。结合７个作业场所和１３６名全体接毒人员的流行病学调查，参照国内外有关异氰酸酯类化合物的接触限值，提出ＰＭＰＰＩ的ＭＡＣ和ＴＷＡ建议值为０４９ｍｇ／ｍ３和０３３ｍｇ／ｍ３。
PMPPI formula contains multiple -NCO groups, the eye, skin and other slight irritation and potential sensitization. Mice oral LD50 7266 1mg / kg, indicating that PMPPI is a low toxic compounds. In 2 hours, the LC50 of inhalation mice was more than 1269mg / m3 and the LC50 of rats was more than 572mg / m3. Sub-chronic inhalation exposure experiments showed that 4.49mg / m3 can be regarded as no visible effect concentration. Ames, UDS test and mouse bone marrow micronucleus test showed that PMPPI is mutagenic at very high doses. Safety factor to be taken 10. Based on the epidemiological investigation of 7 workplaces and 136 allied drug addicts, the proposed MAC and TWA values of PMPPI were proposed to be 049 mg / m3 and 033 mg / m3 according to the exposure limits of isocyanates at home and abroad. .