目的：观察血栓素（ＴＸ）Ａ２合成酶抑制剂ＯＫＹ－０４６对嗜酸性粒细胞（ＥＯＳ）浸润气道的影响，探讨ＴＸＡ２在过敏性气道炎症过程中的作用。方法：应用鸡卵白蛋白（ＯＶＡ）致敏和反复雾化吸入刺激小鼠以复制过敏性气道炎症模型。除对照组外，各实验组小鼠于每天ＯＶＡ刺激前分别给予不同剂量ＯＫＹ－０４６腹腔注射，计数支气管肺泡灌洗液（ＢＡＬＦ）中ＥＯＳ数量，并测定支气管肺泡灌洗液（ＢＡＬＦ）中ＴＸＢ２和６－酮－前列腺素Ｆ１α（６－Ｋｅｔｏ－ＰＧＦ１α）水平。结果：致敏小鼠给予ＯＶＡ刺激后ＢＡＬＦ中ＥＯＳ数、ＴＸＢ２和６－Ｋｅｔｏ－ＰＧＦ１α水平均显著升高，当以ＯＫＹ－０４６处理后，ＢＡＬＦ中的ＥＯＳ明显减小，并呈剂量相关性，而且ＯＫＹ－０４６尚能引起ＴＸＢ２水平呈剂量相关性降低。结论：ＴＸＡ２对于ＥＯＳ浸润到呼吸道具有明显的趋化作用，其合成酶抑制剂对于临床治疗哮喘患者可能会有重要的价值 Objective: To observe the effect of TXY2 synthase inhibitor OKY-046 on eosinophil infiltration in airway and to explore the role of TXA2 in allergic airway inflammation. Methods: Mice were stimulated with ovalbumin (OVA) sensitization and repeated inhalation to replicate the allergic airway inflammation model. Except for the control group, the mice in each experimental group were given different doses of OKY-046 intraperitoneally before OVA stimulation every day, and the number of EOS in bronchoalveolar lavage fluid (BALF) was counted. The levels of TXB2 in bronchoalveolar lavage fluid (BALF) And 6-keto-prostaglandin F1α (6-Keto-PGF1α) levels. Results: The levels of EOS, TXB2 and 6-Keto-PGF1α in BALF of sensitized mice were significantly increased after OVA stimulation. When OKY-046 was treated, the EOS of BALF was significantly reduced and the dose-dependent, And OKY-046 still can cause dose-related reduction TXB2 level. Conclusion: TXA2 has obvious chemotactic effect on the infiltration of EOS into the respiratory tract, and its synthetase inhibitor may have important value in the clinical treatment of patients with asthma