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目的探讨2型糖尿病肾病，早期、临床期患者的生存质量及其影响因素。方法采用KDQOL-SFTM1.3量表对2013年12月~2014年9月昆明医科大学第一附属医院内分泌科、糖尿病科和肾内科住院的103例2型糖尿病肾病(早期)和101例2型糖尿病肾病(临床期)患者进行问卷调查，并对其生存质量进行评估。结果①2型糖尿病肾病(早期)组在SF-36总分及其分支领域得分均显著高于2型糖尿病肾病(临床期)组，差异有统计学意义，<0.05；②早期组在总的肾病相关生活质量、症状与不适、肾脏病对日常生活的影响、肾脏病给生活带来的负担、工作状况、认知功能、社交质量、性功能、睡眠方面的得分均高于临床组，差异有统计学意义(<0.05)，而社会支持方面的生存质量，早期组与临床组无明显差异。结论2型糖尿病肾病(早期)患者的生存质量高于2型糖尿病肾病(临床期)患者，故临床上对于早期糖尿病肾病患者进行积极管理及干预，有助于延缓糖尿病肾病的进展。“,”Objective Investigate the quality of life (QoL)and its related factors of type 2 early period diabetic nephropathy patients and typy 2 clinical diabetic nephropathy patients . Methods From December 2013 to September 2014,with KDQOL-SF?1.3 scale to investigate and assess the quality of life of 103 type 2 early period diabetic nephropathy patients and 101 typy 2 clinical diabetic nephropathy patients.Selecting the patients in endocrinology、diabetes and kidney internal medicine of the First Af iliated Hospital of Kunming Medical University. Results ①The aggregate score of the type 2 early period diabetic nephropathy group in SF-36 and the field of its branches is significantly higher than the clinical group,and the dif erence is statistical y significant ( <0.05);②The aggregate score of the early group in KDTA and the field of its branches including SP,EKD,BKD,WS,CF,QSI,SF1,S is significantly higher than the clinical group,the dif erence is statistical y significant ( <0.05), but they have no statistical y significance in the remaining branch.Conclusion The study shows the quality of life of the early group is higher than the clinical group. So active management and clinical interventions for patients with early diabetic nephropathy, may slow down the progress of diabetic nephropathy.