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目的评价预防性治疗对高校潜在结核感染者结核发病的影响。方法根据系统评价的原则制定检索策略,收集符合纳入标准的文献,提取数据并应用Rev Man 5.1软件进行分析。纳入对象为潜在结核感染者,对照组为空白组、干预组为异烟肼利福喷汀联用方案。合并统计量采用率差。结果 Meta分析结果显示:潜在结核感染者进行预防性治疗至少三个月后,合并后的结核发病率OR 95%CI为0.21(0.14,0.32),得出进行预防性治疗更有效的结论,与对比组有显著性差异。
Objective To evaluate the effect of prophylactic treatment on the incidence of tuberculosis among college students with potential tuberculosis infection. Methods Based on the principles of systematic evaluation, a search strategy was developed to collect documents that met the inclusion criteria. Data were extracted and analyzed using Rev Man 5.1 software. Patients were enrolled as potential tuberculosis infection, control group was blank group, the intervention group is isoniazid rifapentine combination program. Consolidated statistics adoption rate is poor. Results The results of Meta analysis showed that the OR 95% CI of combined tuberculosis incidence was 0.21 (0.14,0.32) after prophylactic treatment of potential tuberculosis patients for at least three months. The conclusion was more effective for preventive treatment and The control group has significant difference.