舒血管肠肽(VIP)在1970年由Said等从猪小肠的提取液中分离出来,1974年确定了氨基酸排列顺序并用合成方法得到证实,1976年发现VIP不但存在于整个胃肠道,在中枢及周围神经系统的某些神经原中也存在。它是调节肽的一种。所谓调节肽,是由弥散性神经内分泌系统所产生的活性多肽,在体内起着循环激素、局部调节剂或神经递质的作用。 The vasoactive intestinal peptide (VIP) was isolated from the extract of porcine small intestine by Said et al. In 1970 and the order of amino acids was confirmed in 1974 and confirmed by synthetic methods. In 1976, VIP was found not only in the entire gastrointestinal tract but also in the central And some neurons in the peripheral nervous system also exist. It is a kind of regulating peptide. The so-called regulatory peptide, is produced by the diffuse neuroendocrine system of active polypeptide, plays a role in the body as a circulating hormone, local regulator or neurotransmitter.