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探讨锌、铜、铁、钙、镁微量元素含量与精神分裂症的关系。方法采用原子吸收分光光度计对７５例精神分裂症病人（Ⅰ型４１例，Ⅱ３４例）和６０名健康对照者的头发锌、铜、铁、钙、镁的含量进行测定。结果（１）精神分裂症病人（Ⅰ、Ⅱ型）头发锌、镁含量较正常对照者低（Ｐ＜０．０１），而铜、铁、钙则增高（Ｐ＜０．０１）；Ⅰ、Ⅱ型间比较，上述元素无差异（Ｐ＞０．０５）。（２）精神分裂症病人男性头发锌、镁含量高于女性（Ｐ＜０．０１）；正常对照者头发钙、镁含量男性高于女性（Ｐ＜０．０１）。（３）抗精神病药治疗４０天后，病人头发锌含量较治疗前增高（Ｐ＜０．０１），铜、钙降低（Ｐ＜０．０１）。结论Ⅰ、Ⅱ型精神分裂症病人头发中存在微量元素的变化。
To explore the relationship between the content of trace elements of zinc, copper, iron, calcium and magnesium and schizophrenia. Methods The content of zinc, copper, iron, calcium and magnesium in the hair of 75 schizophrenic patients (type Ⅰ, n = 34) and 60 healthy controls were measured by atomic absorption spectrophotometer. Results (1) The levels of zinc and zinc in the hair of schizophrenic patients were lower than those of normal controls (P <0.01), while the contents of copper, iron and calcium increased (P <0.01) Ⅱ type comparison, no difference between the above elements (P> 0.05). (2) The content of zinc and magnesium in the hair of schizophrenia patients was higher than that of the women (P <0.01). The content of calcium and magnesium in the hair of the normal controls was higher than that of the female (P <0.01). (3) After 40 days of antipsychotic treatment, the content of zinc in the hair of the patients increased (P <0.01) and the contents of copper and calcium decreased (P <0.01). Conclusion There are trace elements in the hair of type Ⅰ and type Ⅱ schizophrenia patients.