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目的 研究急性心衰患者平均血小板体积(mean platelet volume,MPV)及B型脑钠肽(B-type natriuretic peptide,BNP)浓度变化情况,及其与疾病的严重程度和预后的关系.方法 2015年2～8月就诊于北京友谊医院急诊科的患者,分为急性心衰患者组(AHF)和对照组两组.静脉采血后,通过全自动血液分析系统分析MPV,应用免疫荧光方法测定BNP浓度.结果 研究包括了74例急性心衰患者(AHF),52例对照组患者.AHF组和对照组BNP浓度分别为(1 872±1 179)pg,/mL和(29±21) pg/mL.AHF组MPV水平明显增高(P＜0.05).MPV水平与BNP水平呈正相关(r=0.60,P＜0.05).结论 对于急诊急性心衰患者,MPV值与BNP浓度有关,可以作为心衰严重程度和反映临床状况的指标.“,”Objective To evaluate the correlation between mean platelet volume (MPV) and B-type natriuretic peptide (BNP) concentration,correlating with the severity and prognosis of illness,in patients presenting with acute dyspnea admitted to the emergency department.Methods Data collected from the emergency department of Beijing Friendship hospital from February-August 2015.The patients were divided into acute heart failure (AHF) group and the control group.74 patients with acute heart failure (AHF) and 52 controls were recruited.Blood samples were analyzed using automated hematology system,and BNP concentration measured using a fluorescence immunoassay.Results The concentrations of BNP in patients with acute heart failure and control group were 1872 ± 1179pg / mL and 29 ± 21pg / mL,respectively.MPV levels were significantly higher in the AHF group (P ＜ 0.05).There was significant linear correlation between MPV level and BNP level (r =0.60,P ＜0.05).Conclusion Increased MPV values correlate with BNP concentration,serving as an promising indicator of HF severity and clinical status,in patients with AHF admitted to the emergency department.