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本文以光镜所见为对照,对24例活检胃粘膜腺体扩张进行了超微结构观察。结果单纯性腺体扩张仅有腺上皮细胞表面微绒毛变短,细胞外形规则。异型性腺体扩张的超微结构所见,细胞增生活跃,重度异型性腺体扩张的细胞,间隙增宽,连接发育不良,核形不规则,核内小体增多,同胃腺癌细胞关系密切。提示胃粘膜活检标本的超微结构观察,有助于判定病变性质,对不同性质腺体扩张的癌变过程的研究有重要作用。
In this paper, the ultrastructural observation of 24 cases of biopsy gastric mucosal glandular expansion was performed with light microscopy. Results Simple glandular expansion only showed microvilli on the surface of glandular epithelial cells. The ultrastructure of the dimorphic glands revealed hyperplasia of the cells. The cells with severely atypical glands expanded, the gaps widened, the junctions were poorly developed, the karyotypes were irregular, and the nuclear bodies increased, which was closely related to the gastric adenocarcinoma cells. . The ultrastructural observation of gastric mucosal biopsy specimens is helpful to determine the nature of the lesions and plays an important role in the study of the cancerous processes of different glandular expansions.