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目的:观察低分子肝素联合前列地尔治疗椎基底动脉供血不足的临床疗效。方法:将入选患者86随机分为治疗组44例和对照组42例,治疗组给予脂微球前列地尔10Ug加入生理盐水100mL静滴,1次/d,同时给予低分子肝素钙5000U皮下注射,q12小时,连用14天为一个疗程;对照组用盐酸倍他司汀500mL加曲克芦丁注射液0.4g静滴,1次/d,连用14天为一个疗程;于治疗结束后判定临床疗效及不良反应,并进行统计学分析。结果:治疗组痊愈23例,显效13例,有效7例,无效1例,总有效率97.7%;对照组:痊愈7例,显效16例,有效7例,无效12例,总有效率71.4%。2组比较,治疗组总有效率显著高于对照组(P<0.01)。结论:低分子肝素钙联合前列地尔治疗椎基底动脉供血不足疗效显著,且未见明显不良反应,值得临床推广应用。
Objective: To observe the clinical effect of low molecular weight heparin combined with alprostadil in the treatment of vertebrobasilar insufficiency. Methods: The selected patients were randomly divided into treatment group of 86 86 patients in the treatment group and the control group, 42 patients in the treatment group were treated with lipopolysaccharide alprostadil 10Ug saline 100mL intravenous drip, 1 / d, given low molecular weight heparin 5000U subcutaneous injection , q12 hours, once every 14 days for a course of treatment; the control group with Betahistine hydrochloride 500mL plus Troxerutin 0.4g intravenous infusion, 1 / d, once every 14 days for a course of treatment; at the end of treatment to determine the clinical Efficacy and adverse reactions, and statistical analysis. Results: The treatment group cured 23 cases, markedly effective in 13 cases, effective in 7 cases, ineffective in 1 case, the total effective rate was 97.7%; control group: cured in 7 cases, markedly effective in 16 cases, effective in 7 cases, ineffective in 12 cases, the total effective rate was 71.4% . The total effective rate of the treatment group was significantly higher than that of the control group (P <0.01). CONCLUSION: Low molecular weight heparin combined with alprostadil is effective in treating vertebrobasilar insufficiency. It has no obvious adverse reactions and is worthy of clinical application.