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目的 :检测大肠癌组织中胀亡细胞及MMP - 2。方法 :应用透射电镜和免疫组化方法检测 5 1例大肠癌组织中胀亡细胞和MMP - 2的表达。结果 :①大肠癌组织中可检测到不同时期的胀亡细胞。②大肠癌组织中MMP- 2表达率 5 4 .9% (2 8/ 5 1 ) ,明显高于正常大肠粘膜 (P <0 .0 5 )。③MMP - 2在淋巴结转移组的阳性表达率为 6 9.5 7% (1 6 / 2 3) ,明显高于无淋巴结转移组的 4 2 .86 % (1 2 / 2 8) ;有淋巴结转移组胀亡指数明显低于无淋巴结转移组 (P<0 .0 5 )。④MMP - 2表达阳性组OI高于MMP - 2阴性组。结论 :大肠癌组织中存在胀亡细胞和MMP - 2的表达 ,2者关系密切 ,且均与大肠癌的转移有关。
Objective: To detect peritumoral cells and MMP - 2 in colorectal cancer. Methods: The expressions of peritoneal mesothelial cells and MMP - 2 in 51 colorectal cancer tissues were detected by transmission electron microscopy and immunohistochemistry. Results: ① Colorectal cancer tissue can be detected at different stages of inflamed cells. ② The expression of MMP-2 in colorectal carcinoma was 54.9% (28/51), which was significantly higher than that in normal colorectal mucosa (P <0.05). ③ The positive expression rate of MMP - 2 in lymph node metastasis group was 6 9.57% (16/23), which was significantly higher than 42.86% (12/28) in non - lymph node metastasis group. The index of death was significantly lower than that without lymph node metastasis (P <0.05). OI in MMP - 2 positive group was higher than that in MMP - 2 negative group. Conclusions: The expression of intumescent cells and MMP - 2 in colorectal carcinoma is closely related to the metastasis of colorectal cancer.